The present study examined whether strategy moderated the relationship between visuospatial perspective-taking and empathy. Participants undertook both a perspective-taking task requiring speeded spatial judgements made from the perspective of an observed figure and the Empathy Quotient questionnaire, a measure of trait empathy. Perspective-taking performance was found to be related to empathy in that more empathic individuals showed facilitated performance particularly for figures sharing their own spatial orientation. This relationship was restricted to participants that reported perspective-taking by mentally transforming their spatial (...) orientation to align with that of the figure; it was absent in those adopting an alternative strategy of transposing left and right whenever confronted with a front-view figure. Our finding that strategy moderates the relationship between empathy and visuospatial perspective-taking enables a reconciliation of the apparently inconclusive findings of previous studies and provides evidence for functionally dissociable empathic and non-empathic routes to visuospatial perspective-taking. (shrink)

This paper examined the persistence of individuals’ power in teams and the individual- and team-level factors influencing power maintenance and loss in the long-term. Specifically, and in line with the functional theory of power, we showed that individuals’ state of power in the past exerted a significant behavioral impact on their later state of power, hence, confirming the “power persistence” hypothesis. Furthermore, and in accordance with the conflict theory of power, we found that individuals’ competence positively influenced power above and (...) beyond its persistence. We also showed that individuals’ uncooperative behavior and team performance had a negative and significant effect on individuals’ power above and beyond its persistence. Finally, we discussed the importance of individuals’ power dynamics for effectively managing power struggles in teams. (shrink)

Background Genuine uncertainty on superiority of one intervention over the other is called equipoise. Physician-investigators in randomized controlled trials need equipoise at least in studies with more than minimal risks. Ideally, this equipoise is also present in patient-participants. In pediatrics, data on equipoise are lacking. We hypothesize that 1) lack of equipoise at enrolment among parents may reduce recruitment; 2) lack of equipoise during participation may reduce retention in patients assigned to a less favoured treatment-strategy. Methods We compared preferences of (...) parents/patients at enrolment, documented by a questionnaire, with preferences developed during follow-up by an interview-study to investigate equipoise of child-participants and parents in the BeSt-for-Kids-study. This trial in new-onset Juvenile Idiopathic Arthritis-patients consists of three strategies. One strategy comprises initial treatment with a biological disease-modifying-antirheumatic-drug, currently not standard-of-care. Semi-structured interviews were conducted with 23 parents and 7 patients, median 11 months after enrolment. Results Initially most parents and children were not in equipoise. Parents/patients who refused participation, regularly declined due to specific preferences. Many participating families preferred the biological-first-strategy. They participated to have a chance for this initial treatment, and would even consider stopping trial-participation when not randomized for it. Their conviction of superiority of the biological-first strategy was based on knowledge from internet and close relations. According to four parents, the physician-investigator preferred the biological-first-strategy, but the majority stated that she had no preferred strategy. In phase 2, preferences tended to change to the treatment actually received. Conclusions Lack of equipoise during enrolment did not reduce study recruitment, mainly due to the fact that preferred treatment was only available within the study. Still, when developing a trial it is important to evaluate whether the physicians’ research question is in line with preferences of the patient-group. By exploring so-called ‘informed patient-group’-equipoise, successful recruitment may be enhanced and bias avoided. In our study, lack of equipoise during trial-participation did not reduce retention in those assigned to a less favoured option. We observed a change for preference towards treatment actually received, possibly explained by comparable outcomes in all three arms. (shrink)

The current situation around COVID-19 portrays a threat to us in several ways: It imposes uncertainty, a lack of control and reminds us of our own mortality. People around the world have reacted to these threats in seemingly unrelated ways: From stockpiling yeast and toilet paper to favoring nationalist ideas or endorsing conspiratorial beliefs. According to the General Process Model of Threat and Defense the confrontation with a threat - a discrepant experience - makes humans react with both proximal and (...) distal threat responses. While the proximal response manifests in behavioral inhibition that leads to heightened anxious arousal and vigilance, distal responses seek to lower behavioral inhibition and the associated state of anxiety and vigilance through engaging in distal defenses. In the present research, we propose that the reactions to COVID-19 may represent distal defense strategies to the pandemic (in the form of environmental or group related worldview defenses) and therefore can be explained and forecasted by the model. Thus we hypothesized increased perceived COVID-19 threat perception to lead to a proximal threat response in the form of heightened behavioral inhibition. This, in return, should enhance the use of distal defenses (i.e.: several ingroup biases, system justification and conspiratorial beliefs) overlapping with the reactions observed as a response to COVID-19. This hypothesized mediated effect of increased perceived COVID-19 threat on distal defenses was tested in two pre-registered studies: In Study 1 (N = 358) results showed perceived COVID-19 threat to be related to behavioral inhibition and in turn to be associated with increased distal defenses (i.e., higher entitativity, control restoration motivation, passive party support). In Study 2 (N = 348) we manipulated COVID-19 threat salience and found results suggesting the distal defenses of system justification and conspiratorial beliefs to be mediated by the proximal threat response. The results of the present research hint towards a common mechanism through which the seemingly unrelated reactions to COVID-19 can be explained. The results might help to predict future behavior during the COVID-19 pandemic and design measures to counteract detrimental effects of the pandemic. (shrink)

Research suggests that sedentary behavior is negatively associated with cognitive outcomes. Interrupting prolonged sitting has been shown to improve cognitive functions, including executive functioning, which is important for academic performance. No research has been conducted on the effect of standing on EF in VET students, who make up a large proportion of the adolescent population and who are known to sit more than other students of this age. In this study, we investigated the acute effects of reducing SB by short (...) time standing on EF in vocational education and training students. In a randomized crossover study, 165 VET students were first taught for 15 min in seated position. After this, they performed while seated the Letter Memory Test for updating, and the Color Shape Test for shifting and inhibition. Students were randomly assigned to a sitting or standing condition. All students were taught again for 15 min and then took the same tests in the condition they were allocated to, respectively, standing or seated. After 1 week, the test procedure was repeated, in which students switched conditions. Mixed model analyses showed no significant effect of sitting or standing on updating, shifting, or inhibition. Also, no significant differences were found for the order of condition on updating, shifting, or inhibition. Our results suggest that 40 min of standing does not significantly influence EF among VET students. (shrink)

Looking Beneath the Surface explores Arab-Islamic and Western perspectives on medical ethical issues: genetic research and treatment, abortion, organ donation, and palliative sedation and euthanasia. The contributions in this volume discuss the state of the art, the role of laws, counseling, and spiritual counseling in the decision-making process. The different approaches to the ethical issues, ways of moral reasoning, become clear in these contributions, especially the role of tradition for Islam and the importance of autonomy for the West. Beneath the (...) differences, however, the reader will also discover common values, such as the role of dignity and the value of life, and similar practices. Some of the main differences are sociocultural in nature, rather than religious as such. Well-known experts in the fields of medicine and ethics have contributed to this volume from different religious and secular backgrounds. The book offers a carefully written introduction and final chapter on intercultural comparisons. Looking Beneath the Surface is more than a collection of writings on issues in medical ethics: it helps the reader to compare different paradigms of accountability and moral reasoning. (shrink)

Problem: Visions of technology, future scenarios, guiding visions represent imaginations of future states of affairs that play a functional role in processes of technological research, development and innovation—e.g. as a means to create attention, communication, coordination, or for the strategic exertion of influence. Since a couple of years there is a growing attention for such imaginations of futures in politics, the economy, research and the civil society. This trend concerns technology assessment as an observer of these processes and a consultant (...) on the implications of technology and innovation. TA faces increasing demands to assess imaginations of futures that circulate in the present and to participate in shaping these through scenarios or foresights. More than ever, this raises the question, which propositions can be made based on these imaginations by TA and how this can be used in advisory practices. Imaginations of futures are relevant for TA not as predictions but in their significance and effectiveness in the present, which need to be understood and assessed.Contents: This discussion paper outlines how present significance and effects of imagined futures in technological research and innovation processes can be conceived and analyzed. In this paper, all forms of imaginations of technology futures will be called “socio-technical futures” because within them technological developments and social changes are interwoven and inseparably interrelated. In this paper, we discuss why TA should analyze socio-technical futures, how such analyses can grasp the societal conditions that are expressed in the imagined futures and how these become effective in processes of technology development, communication, decision making etc. We raise the question which self-reflexive positioning or possible realignment of TA is needed as a response to its increased concern with assessing and even co-producing socio-technical futures. The latter is often demanded regarding the growing attention by politics and publics to imaginations of futures with wide temporal and spatial reach.Addressee of this paper is the TA community in a broader sense. The aim is to sensitize colleagues for the topic and its challenges, to consolidate discussions and to provide theoretical and methodical suggestions for research in TA and related advisory practices with respect to socio-technical futures. This paper has been originally initiated during the workshop “The present of technological futures-theoretical and methodical challenges for Technology Assessment”, in which all of the paper’s authors participated. The contents of this discussion paper are preliminary results that shall initiate and guide further discussions. (shrink)

This article deals with quotatives–overt marks that indicate quotations–consisting in iti/ti or containing vuttaṃ which are used in Pāli commentarial literature to signal the occurrence of a quotation. We distinguish two types, namely, “general quotatives” and “individual quotatives”. The former are universally valid. They are widely acknowledged and used in various text corpora over several centuries. The latter are defined by an author solely for usage in his commentary. In the first part of our contribution we describe the implications connected (...) with the usage of quotatives, and depict the specific problems which may arise when a text including “individual quotatives” is tacitly borrowed. In the second part we present some of the most common “general quotatives” formed with the words iti/ti and vuttaṃ. We aim at pointing out in which text layers a quotative is applied, for which text layers it is used, when it was in and when out of fashion. (shrink)

Spiel und Arbeit gelten oft als Gegensätze: Das Spiel als freie Betätigung menschlicher Vermögen, die Arbeit als deren Subordination unter einen äußeren Zweck. Die Festlegung des Spiels auf konsequenzlose Wiederholbarkeit hat ihm den Ruf des Unernsten eingetragen, während das Abzwecken der Arbeit auf die Nützlichkeit ihres Resultats im Bund mit der Sorge ums Dasein steht. Auf einen zweiten Blick scheint dieser Gegensatz jedoch, gerade in den hochentwickeltsten Ausprägungen beider Tätigkeitsformen, zu verschwinden. So kann eine hochgradige Rationalisierung von Spielpraktiken in Arbeit (...) umschlagen, wie etwa im Leistungssport, oder ein komplexer Arbeitsvorgang selbstzweckhafte Momente und Eigendynamiken gewinnen, die ihm Spielcharakter verleihen. Auch andere technologische Entwicklungen geben Anlass dazu, das Verhältnis von Spiel und Arbeit noch einmal grundsätzlich zu bedenken, etwa im Hinblick auf: adaptive Systeme in der Robotik, serious games, Kreativitätstechniken in Unternehmenskulturen, wissenschaftliche Experimentalanordnungen, Online-Rollenspiele oder die Kommodifizierung nicht-zweckrationaler Lebensvollzüge, die traditionell vom Begriff produktiver Arbeit ausgeschlossen waren – einschließlich der Spielräume, die durch neue Umwelt- und Biotechniken erschlossen werden. Die Beschaffenheit der jeweils zum Einsatz kommenden Mittel und Verfahren sowie die Setzung, Variation oder Preisgabe von Zwecken können den Charakter von Spiel und Arbeit sowie ihr Verhältnis zueinander bestimmen oder verändern. Mit Beiträgen von Francesco Amigoni, Andreas Brenneis, Petra Gehring, Armin Grunwald, Florian Heßdörfer, Wolfram Ette, Christoph Hubig, Andreas Kaminski, Nicole C. Karafyllis, Christian Klager, Alexander Kluge, Uwe Küster, Oliver Laas, Hildrun Lampe, Pieter Lemmens, Stefan Meißner, Alfred Nordmann, Felix Raczkowski, Markus Rautzenberg, Michael Resch, Nicole J. Saam, Viola Schiaffonati, Alexander Schmidl, Jan C. Schmidt und G. Günter Voß. (shrink)

Mitochondrial respiration is the predominant source of ATP. Excessive rates of electron transport cause a higher production of harmful reactive oxygen species (ROS). There are two regulatory mechanisms known. The first, according to Mitchel, is dependent on the mitochondrial membrane potential that drives ATP synthase for ATP production, and the second, the Kadenbach mechanism, is focussed on the binding of ATP to Cytochrome c Oxidase (CytOx) at high ATP/ADP ratios, which results in an allosteric conformational change to CytOx, causing inhibition. (...) In times of stress, ATP‐dependent inhibition is switched off and the activity of CytOx is exclusively determined by the membrane potential, leading to an increase in ROS production. The second mechanism for respiratory control depends on the quantity of electron transfer to the Heme aa3 of CytOx. When ATP is bound to CytOx the enzyme is inhibited, and ROS formation is decreased, although the mitochondrial membrane potential is increased. (shrink)

Two posttranslational lipid modifications present on all Hedgehog (Hh) morphogens—an N‐terminal palmitate and a C‐terminal cholesterol—are established and essential regulators of Hh biofunction. Yet, for several decades, the question of exactly how both lipids contribute to Hh signaling remained obscure. Recently, cryogenic electron microscopy revealed different modes by which one or both lipids may contribute directly to Hh binding and signaling to its receptor Patched1 (Ptc). Some of these modes demand that the established release factor Dispatched1 (Disp) extracts dual‐lipidated Hh (...) from the cell surface, and that another known upstream signaling modulator called Scube2 chaperones the dual‐lipidated morphogen to Ptc. By mechanistically and biochemically aligning this concept with established in vivo and recent in vitro findings, this reflection identifies remaining questions in lipidated Hh transport and evaluates additional mechanisms of Disp‐ and Scube2‐regulated release of a second bioactive Hh fraction that has one or both lipids removed. (shrink)

In this article I try to refute the so-called "libertarian" theory of free will, and to examine how our conclusion ought to modify our common attitudes of praise and blame. In attacking the libertarian view, I shall try to show that it cannot be consistently stated. That is, my dscussion will be an "analytic-philosophic" one. I shall neglect what I think is in practice an equally powerful method of attack on the libertarian: a challenge to state his theory in such (...) a way that it will fit in the modern biology and psychology, which are becoming increasingly physicalistic. (shrink)

Which is more important, tragedy or treatise? This question, which was posed as early as in antiquity, cannot easily be answered since tragedy has reflective passages on existential issues, just as philosophy uses tragedy for argumentation or takes the dramatic form itself. This is particularly evident in the work of the ‘philosophus scaenicus’ Euripides, in Plato, whose understanding of tragedy as expressed in the Symposium and the Laws is discussed here, and with Cicero and Seneca, who were both authors of (...) treatises and verses of tragedy. They constitute the focus of this volume, which also examines the function of the poetry quotations in Chrysippus and finally the significance of tragedy for Hannah Arendt’s political analysis. With contributions by Sandra Erker, Susanna Fischer, Thomas Gärtner, Andreas Heil, Argyri Karanasiou, Giovanni Panno, Robert C. Pirro, Tobias Riedl and Petra Schierl. (shrink)

In our papers on the rationality of magic, we distinghuished, for purposes of analysis, three levels of rationality. First and lowest (rationalitYl) the goal directed action of an agent with given aims and circumstances, where among his circumstances we included his knowledge and opinions. On this level the magician's treatment of illness by incantation is as rational as any traditional doctor's blood-letting or any modern one's use of anti-biotics. At the second level (rationalitY2) we add the element of rational thinking (...) or thinking which obeys some set of explicit rules, a level which is not found in magic in general, though it is sometimes given to specific details of magical thinking within the magical thought-system. It was the late Sir Edward E. Evans-Pritchard who observed that when considering magic in detail the magician may be as consistent or critical as anyone else; but when considering magic in general, or any system of thought in general, the magician could not be critical or even comprehend the criticism. Evans-Pritchard went even further: he was sceptical as to whether it could be done in a truly consistent manner: one cannot be critical of one's own system, he thought. On this level (rationalitY2) of discussion we have explained (earlier) why we prefer to wed Evans Pritchard's view of the magician's capacity for piece-meal rationality to Sir James Frazer's view that magic in general is pseudo-rational because it lacks standards of rational thinking. (shrink)

Cuprins CONTUR Re-Introducere sau: Dincolo de „teoria şi practica” informării şi documentării – Spre o hermeneutică posibilă şi necesară Proiectul şi Programul PHILOBIBLON( în noua formulare) FOCUS Dana Stana, Omonimia şi paronimia în bibliologie Victoria Frâncu, Profesia de bibliotecar la graniţa dintre spaţiul bibliotecii şi ciberspaţiu Olimpia Curta, Laboratorul de informatică şi profesioniştii săi Ionel Enache, Fundamentele teoretice ale marketingului de bibliotecă Maria Petrescu, Bibliotecile digitale şi impactul lor asupra tinerilor Adriana Szekely, Liana Grigore, Bibliorev – în continuă schimbare István (...) Király V., Proiect în vederea Acreditării ISI al revistei PHILOBIBLON Valeria Salánki, Cultura organizaţională. Propunere de studiu asupra culturii organizaţionale – octombrie 2008 Marian Petcu, Originile faptului divers în presa română Tudor-George Pereverza Expresia bibliografică a Iconografiei eminesciene (Fotografie şi artă plastică, 1939-1989) Vlad A. Codrea, Gabriela-Rodica Morărescu, Forray Erzsébet, Catalogus Raritatum et Benefactorum, un manuscris reprezentativ din perioada de început a Muzeului de Ştiinţele Naturii din Aiud 4 Alin Mihai Gherman, Pornind de la o Bucoavnă necunoscută Roxana Bălăucă, Tipărituri franceze în colecţiile BCU „Lucian Blaga”: secolul al XVIII-lea Maria-Stela Constantinescu-Matiţa, Szabó Károly – bibliotecar, bibliograf şi istoric Roxana Bălăucă, Theodor Aman în Donaţia Sion Margareta Berchez, Îmbogăţirea colecţiilor Bibliotecii Universităţii de Ştiinţe Agricole şi Medicină Veterinară Cluj-Napoca prin schimbul de publicaţii de-a lungul timpului Ioana Rotund, O oază francofonă la Cluj Ilona Okos-Rigó, Biblioteca şi Grădina Botanică Clujeană Gabriela Pop, Institutul de Iudaistică şi Istorie Evreiască „Dr. Moshe Carmilly” şi Biblioteca de Studii Iudaice Mariana Falup, Împrumutul interbibliotecar intern şi internaţional şi livrarea de documente la B.C.U. Cluj-Napoca ORIZONTURI Doru Radosav, Viaţa ca alterego. Petrea Icoanei: travesti şi clandestinitate în mişcarea de rezistenţă anticomunistă Ionuţ Costea, Mitbiografia între propagandă şi memorie Gabriela Morărescu ;Vlad Codrea, Preocupări pentru cunoaşterea şi protecţia naturii în scrierile unui entuziast naturalist al secolului XIX: Basiliu Basiota Alin Mihai Gherman, Vechi lexic bibliotecăresc Raluca Betea, Influenţa artei Renaşterii asupra decoraţiei icoanelor din secolele XVI-XVIII din Transilvania şi Maramureş 5 Monica Mureşan, Căsătoria civilă ca aspect al modernizării societăţii transilvănene la sfârşitul secolului al XIX –lea. – Discurs oficial şi receptare socială reflectate în presa vremii Ancuţa-Lăcrimioara Chiş, Diferenţa şi discriminarea socio-politică a femeii Irina Petraş, Casa, locul vieţii (fragmente) Monica Mureşan Pentru o istorie a morţii în peisajul istoriografic românesc - prezentarea unor contribuţii colective recente: Religiozitate şi atitudini în faţa morţii în spaţiul transilvan din premodernitate până în secolul XX, coord. Mihaela Grancea, 2005 şi Discursuri despre moarte în Transilvania secolelor XVI-XX, coord Mihaela Grancea şi Ana Dumitran, 2006. REFLEXII Olimpia Curta, Reviste electronice. Baze şi perspective de Alice Keller – Recenzie Adrian Grănescu, Arhitectura Clinicilor Universitare din Cluj 1886-1903 Dorina Buia, Itinerar de suflet la Tăul Muced Raluca Soare, De la teoriile ataşamentului la tehnicile de intervenţie în psihoterapie. (Školka Enikő – Teorii explicative, Modele şi Tehnici de intervenţie în psihologie clinică şi psihoterapie) Sidonia Nedeianu Grama, Mitbiografia politică în istoria orală Raluca Soare, Opera bibliothecariorum 1990-2007 – Recenzie Ionuţ Costea, Kovács Mária, A kolozsvári „Lucian Blaga” Központi Egyetemi Könyvtár 19. századi magyar nyelvű kéziratainak katalógusa. Első kötet: történelmi és földrajzi kéziratok/ Catalogul manuscriselor maghiare din secolul al 19-lea din colecţiile Bibliotecii Centrale Universitare „Lucian Blaga” Volumul I: Manuscrise de istorie şi geografie, Editura Argonaut, Cluj-Napoca, 2007, 218 p. – Recenzie 6 Ana Maria Căpâlneanu, Lola Maria Petrescu – Biblioteca şi provocările secolului XXI, Cluj-Napoca: Risoprint, 2007 István Király V, Bibliografia ca instrument al clarificării de sine Kinga Tamás, Viorica Sâncrăian - un coleg şi un bibliotecar de excepţie În colecţia BIBLIOTHECA BIBLIOLOGICA au apărut Revista PHILOBIBLON – Volumele apărute. (shrink)

The flowering of creative and speculative philosophy that emerged in modern Europe--particularly in Germany--is a thrilling adventure story as well as an essential chapter in the history of philosophy. In this integrative narrative, Solomon provides an accessible introduction to the major authors and movements of modern European philosophy, including the Enlightenment and Romanticism, Rousseau, German Idealism, Kant, Fichte, Schelling and the Romantics, Hegel, Schopenhauer, Kierkegaard, Feuerbach, Max Brentano, Meinong, Frege, Dilthey, Bergson, Nietzsche, Husserl, Freud, Wittgenstein, Heidegger, hermeneutics, Sartre, Postmodernism, Structuralism, (...) Foucault, and Derrida. (shrink)

La Semaine d'épigraphie créto-mycénienne a été organisée par l'École française d'Athènes du 24 au 28 mars 1998, dans le but de réunir, pour quelques séances de travail, des savants reconnus et de jeunes doctorants spécialisés dans l'étude des écritures linéaires A et B. Chacun des participants a présenté un état de ses recherches personnelles : M.-L. Bech Nosch, L'administration des textes en Crète centrale, hors des séries Lc/Le/Ln ; Chr. Boulotis, Les nouveaux documents en linéaire A d'Akrotiri (Théra) : remarques (...) préliminaires ; P. Carlier, wa-na-ka derechef. Nouvelles réflexions sur les royautés mycéniennes; P. Darcque, Archives réelles, archives virtuelles en linéaire B; H. Landenius Enegren, Some Problems of the Prosopography of Knossos; J. T. Killen, The Pylos Ta Tablets Revisited ; S. Lupack, The Role of the Religious Sector in Mycenaean Economics; J.-P. Olivier, Le syllabaire chyproclassique : un inventaire; M. Perna, Gli ideogrammi dei vasi in lineare A ; Fr. Rougemont, Quelques problèmes liés à l'étude des «collecteurs» dans les tablettes en linéaire B; M.-St. Speciale, Gli antroponimi in lineare B di Cnosso e la Creta del TM II-III; M. Tsipopoulou, The Hieroglyphic Archive at Petras, Siteia ; C. Varias Garcia, Antroponimia micénica en las tablillas de h sene B de Cnoso y en Micenas. (shrink)

Investigates the resolution of contradictions and ambiguous derogations in a code, by means of the imposition of partial orderings. Although formulated as a study in the logic of norms, it provided the initial ideas for work on the logic of theory (or belief) change, developed by the authors in a series of papers by the authors and Peter Gardenfors beginning in 1985.

This book discusses American pragmatism as it is found in the writings of its three major advocates: Charles S. Peirce, William James, and John Dewey. This book discusses each man's definition of pragmatism and shows how each of them applied it to one basic concept: Peirce to a theory of reality; James to a notion of truth; and Dewey to the concept of God.

The Phenomenology of Spirit was Hegel's grandest experiement, changing our vision of the world and the very nature of philosophical enterprise. In this book, Solomon captures the bold and exhilarating spirit, presenting the Phenomenology as a thoroughly personal as well as philosophical work. He begins with a historical introduction, which lays the groundwork for a section-by-section analysis of the Phenomenology. Both the initiated as well as readers unacquainted with the intricacies of German idealism will find this to be an accessible (...) and exciting introduction to this great philosopher's monumental work. (shrink)

'Original and provocative . . . engagingly written. (C Fred Alford) counters Levinas's notorious obscurity with a goodly dose of transparency' - John Lechte, Macquarrie University Abstract and evocative, writing in what can only be ...

The US neutrino community gathered at the Workshop on the Intermediate Neutrino Program at Brookhaven National Laboratory February 4-6, 2015 to explore opportunities in neutrino physics over the next five to ten years. Scientists from particle, astroparticle and nuclear physics participated in the workshop. The workshop examined promising opportunities for neutrino physics in the intermediate term, including possible new small to mid-scale experiments, US contributions to large experiments, upgrades to existing experiments, R&D plans and theory. The workshop was organized into (...) two sets of parallel working group sessions, divided by physics topics and technology. Physics working groups covered topics on Sterile Neutrinos, Neutrino Mixing, Neutrino Interactions, Neutrino Properties and Astrophysical Neutrinos. Technology sessions were organized into Theory, Short-Baseline Accelerator Neutrinos, Reactor Neutrinos, Detector R&D and Source, Cyclotron and Meson Decay at Rest sessions.This report summarizes discussion and conclusions from the workshop. (shrink)

Bioethics is quickly developing into a vast discipline, with rapidly expanding areas of study and practice, and a rapidly expanding literature. Creating anthologies that provide useful overviews of bioethics is, consequently, a daunting task: many areas important to bioethics must be left out and depth of critical analysis must suffer. The editors of this volume—now in paperback in the Blackwell Companions to Philosophy series—skilfully address these challenges. The result is a comprehensive and authoritative anthology, providing balanced analyses of major debates (...) and trends in bioethics. Unlike in most bioethics anthologies, each of the 46 articles in this volume is written specifically for the anthology. The authors comprise an impressive group of international scholars, most with well established expertise in the subjects about which they write. Rather than merely articulating a position and defending it, …. (shrink)

Ivancovsky et al. propose a novelty-seeking model linking curiosity to creativity. This commentary suggests integrating their work with a stage-based creativity model for additional insights. It also encourages readers to address knowledge gaps identified by the authors, including factors that trigger the pursuit of creative solutions. We aim to refine theory and direct future research to clarify the complex curiosity–creativity relationship.

Rare Disease research has seen tremendous advancements over the last decades, with the development of new technologies, various global collaborative efforts and improved data sharing. To maximize the impact of and to further build on these developments, there is a need for model consent clauses for rare diseases research, in order to improve data interoperability, to meet the informational needs of participants, and to ensure proper ethical and legal use of data sources and participants’ overall protection. A global Task Force (...) was set up to develop model consent clauses specific to rare diseases research, that are comprehensive, harmonized, readily accessible, and internationally applicable, facilitating the recruitment and consent of rare disease research participants around the world. Existing consent forms and notices of consent were analyzed and classified under different consent themes, which were used as background to develop the model consent clauses. The IRDiRC-GA4GH MCC Task Force met in September 2018, to discuss and design model consent clauses. Based on analyzed consent forms, they listed generic core elements and designed the following rare disease research specific core elements; Rare Disease Research Introductory Clause, Familial Participation, Audio/Visual Imaging, Collecting, storing, sharing of rare disease data, Recontact for matching, Data Linkage, Return of Results to Family Members, Incapacity/Death, and Benefits. The model consent clauses presented in this article have been drafted to highlight consent elements that bear in mind the trends in rare disease research, while providing a tool to help foster harmonization and collaborative efforts. (shrink)